Rapid Aldosterone Signaling and Vascular Reactivity: Relax or Don't Do It
نویسندگان
چکیده
منابع مشابه
GPR30, mineralocorticoid receptors, and the rapid vascular effects of aldosterone.
It is now generally accepted that in common with other steroid hormones aldosterone has rapid nongenomic effects, in addition to those mediated via DNA-directed, RNAmediated protein synthesis. The currently accepted physiology of aldosterone was primarily charted by nephrologists, who understandably focused on the epithelial (and genomic) effects of aldosterone on urinary electrolytes, and the ...
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متن کاملVascular actions of aldosterone.
Aldosterone exerts direct effects on the vascular system by inducing oxidative stress, inflammation, hypertrophic remodeling, fibrosis, and endothelial dysfunction. Aldosterone exerts its effects through genomic and nongenomic pathways in a mineralocorticoid receptor (MR)-dependent or independent manner. Other aldosterone receptors such as GPR30 have been identified. A tight relation exists bet...
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ژورنال
عنوان ژورنال: Journal of Cardiovascular Pharmacology
سال: 2009
ISSN: 0160-2446
DOI: 10.1097/fjc.0b013e3181c37ddc